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Characterization of M-tuberculosis strains from West African patients by spoligotyping

被引：13
作者：
Niang, MN
de la Salmoniere, YG
Samb, A
Hane, AA
Cisse, MF
Gicquel, B
Perraut, R
机构：
[1] Inst Pasteur Dakar, Immunol Lab, Dakar, Senegal
[2] Univ Cheikh Anta Diop, Fac Med & Pharm Dakar, Lab Mycobacteries, Dakar, Senegal
[3] Hop Fann, Serv Pneumophtisiol, Dakar, Senegal
[4] Inst Pasteur, Unite Genet Mycobacterienne, F-75724 Paris 15, France
来源：
MICROBES AND INFECTION | 1999年 / 1卷 / 14期
关键词：
Mycobacterium tuberculosis strains; West Africa; spoligotyping; PCR;
D O I：
10.1016/S1286-4579(99)00243-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Analysis of Mycobacterium tuberculosis strains was carried out using isolates collected from 69 Senegalese and 20 Ivory Coast tuberculosis patients. These 89 isolates were typed by means of the spoligotyping technique, showing clusterized populations of bacterial strains. In the Senegalese patients, 35 genetic profiles were observed with 10 clusters of spoligotypes from 44 isolates. Among Ivory Coast patients, 11 spoligotypes were found for 20 isolates. A particular cluster of isolates was evident both in Senegalese (10) and Ivory Coast (11) patients. These results show the existence of polymorphism of the direct repeat region for African M. tuberculosis strains. However they suggest that additionnal markers are needed for accurate epidemiological studies in areas that are highly endemic for tuberculosis. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
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收藏
页码：1189 / 1192
页数：4
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