Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

被引：44

作者：

deBont, DBA

Dijkstra, GDH

denHartog, JAJ

Liskamp, RMJ

机构：

[1] UNIV UTRECHT,UTRECHT INST PHARMACEUT SCI,DEPT MED CHEM,NL-3508 TB UTRECHT,NETHERLANDS

[2] SOLVAY PHARMA,RES LABS,NL-1308 DA WEESP,NETHERLANDS

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00565-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using Boc or Fmoc-protected beta-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3035 / 3040

页数：6

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