Microwave-accelerated Wittig olefination of β-chloroacroleins

被引：14

作者：

Bera, Rabin ^{[2
]}

Dhananjaya, G. ^{[2
]}

Singh, Shambu Nath ^{[2
]}

Kumar, Rajender ^{[2
]}

Mukkanti, K. ^{[3
]}

Pal, Manojit ^{[1
]}

机构：

[1] Matrix Labs Ltd, R&D Ctr, New Drug Discovery, Jinnaram Mandal 502325, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India

[3] JNT Univ, Inst Sci & Technol, Div Chem, Hyderabad 500072, Andhra Pradesh, India

来源：

TETRAHEDRON | 2009年 / 65卷 / 07期

关键词：

EMPLOYING STABILIZED YLIDES; PHOSPHORUS YLIDES; ALDEHYDES; KETONES; IRRADIATION; CHALCONES; ESTERS; WATER; RING;

D O I：

10.1016/j.tet.2008.12.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first microwave assisted Wittig reactions of beta-chloroacroleins with a stabilized ylide are described here. A combination of sodium ethoxide and toluene was found to be optimum and using this reaction condition a number of alkenyl-substituted benzopyran/benzo[b]oxepine/2-chromenone derivatives were prepared within few minutes. The microwave mediated process was found to be comparable with the conventional Wittig reaction in terms of product yields. All the products isolated were found to have E-geometry around the C=C bond. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1300 / 1305

页数：6

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