Tight junctions: Closing in on the seal

被引:41
作者
Anderson, JM
Van Itallie, CM
机构
[1] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06580 USA
[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06580 USA
关键词
D O I
10.1016/S0960-9822(00)80105-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The claudins have recently been identified as a large family of transmembrane proteins located at tight junctions between epithelial cells; they create the paracellular diffusion barrier and, surprisingly, may also confer channel-like selectivity for passage of solutes through the tissue barrier. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:R922 / R924
页数:3
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