Changes of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) after autologous hematopoietic stem cell transplantation in multiple sclerosis

被引：13

作者：

Blanco, Y

Saiz, A

Carreras, E

Graus, F

机构：

[1] Univ Barcelona, IDIBAPS, Hosp Clin, Serv Neurol, E-08036 Barcelona, Spain

[2] Univ Barcelona, IDIBAPS, Hosp Clin, Bone Marrow Transplantat Unit, E-08007 Barcelona, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 153卷 / 1-2期

关键词：

multiple sclerosis; transplantation; matrix metalloproteinase; real time polymerase chain reaction;

D O I：

10.1016/j.jneuroim.2004.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elevated levels of matrix metalloproteinase-9 (MMP-9) associates with predictors of multiple sclerosis (MS) activity. We analysed serum levels and mRNA expression of MMP-9 and its inhibitor TIMP-1 in peripheral mononuclear cells of 14 MS patients after autologous hematopoietic stem cell transplantation (AHSCT). All but 2 patients stabilized after AHSCT. A significant decrease of MMP-9 levels was seen up to 36 months after AHSCT. TIMP-1 levels did not change. MMP-9 mRNA levels correlated with the CD4+ T cell count (p<0.0001). The significant and persistent change in MMP-9 activity after AHSCT may be caused in part by the effect of AHSCT in the CD4+ T cell count. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：190 / 194

页数：5

共 15 条

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Carreras E, 2003, HAEMATOLOGICA, V88, P306

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