Chemiosmotic mechanism of antimicrobial activity of Ag+ in Vibrio cholerae

被引：571

作者：

Dibrov, P

Dzioba, J

Gosink, KK

Häse, CC

机构：

[1] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[2] Univ Manitoba, Dept Microbiol, Winnipeg, MB R3T 2N2, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2668-2670.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag+ in low concentrations has not been elucidated. Here, we show that low concentrations of Ag+ induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.

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页码：2668 / 2670

页数：3

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