Parkinson's disease

被引：1768

作者：

Lees, Andrew J. ^{[1
]}

Hardy, John

Revesz, Tamas

机构：

[1] UCL, Dept Mol Neurosci, London WC1N 3BG, England

来源：

LANCET | 2009年 / 373卷 / 9680期

基金：

英国医学研究理事会;

关键词：

ALPHA-SYNUCLEIN PATHOLOGY; DEEP-BRAIN-STIMULATION; LEWY BODY DISEASE; PROGRESSIVE SUPRANUCLEAR PALSY; MITOCHONDRIAL DYSFUNCTION; SUBCUTANEOUS APOMORPHINE; PYRAMIDAL DEGENERATION; VASCULAR PARKINSONISM; VISUAL HALLUCINATIONS; NEUROTROPHIC FACTOR;

D O I：

10.1016/S0140-6736(09)60492-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Parkinson's disease is a common progressive bradykinetic disorder that can be accurately diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions. The main known risk factor is age. Susceptibility genes including a-synuclein, leucine rich repeat kinase 2 (LRRK-2), and glucocerebrosidase (GBA) have shown that genetic predisposition is another important causal factor. Dopamine replacement therapy considerably reduces motor handicap, and effective treatment of associated depression, pain, constipation, and nocturnal difficulties can improve quality of life. Embryonic stem cells and gene therapy are promising research therapeutic approaches.

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页码：2055 / 2066

页数：12

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