Resistin/ADSF/FIZZ3 in obesity and diabetes

被引：21

作者：

Sul, HS ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2004年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.tem.2004.06.005

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The role of adipocyte-secreted resistin/adipocyte-specific secretory factor (ADSF)/FIZZ3 in obesity and diabetes has been controversial at best. Recently generated resn knockout mice showed normal glucose and insulin sensitivity with lower fasting glucose levels. Upon feeding with a high-fat diet, the knockout mice exhibited increased glucose tolerance with decreased hepatic glucose output, possibly due to phosphorylation and activation of AMP-activated protein kinase and suppression of gluconeogenic genes. In comparison, transgenic mice overexpressing a dominant negative form of resistin/ADSF/FIZZ3 showed increased adiposity with elevated leptin and adiponectin levels, accompanying enhanced glucose tolerance and insulin sensitivity both on chow and high-fat diets. Although its underlying mechanisms need further elucidation, the in vivo studies demonstrate a role of resistin/ADSF/FIZZ3 in obesity and insulin resistance.

引用

页码：247 / 249

页数：3

共 25 条

[1]

Regulation of fasted blood glucose by resistin [J].

Banerjee, RR ;

Rangwala, SM ;

Shapiro, JS ;

Rich, AS ;

Rhoades, B ;

Qi, Y ;

Wang, J ;

Rajala, MW ;

Pocai, A ;

Scherer, PE ;

Steppan, CM ;

Ahima, RS ;

Obici, S ;

Rossetti, L ;

Lazar, MA .

SCIENCE, 2004, 303 (5661) :1195-1198

[2]

Barthel A, 2002, ENDOCRINOLOGY, V143, P3183, DOI 10.1210/endo.143.8.8792

[3]

Inhibition of adipocyte differentiation by resistin-like molecule α -: Biochemical characterization of its oligomeric nature [J].

Blagoev, B ;

Kratchmarova, I ;

Nielsen, MM ;

Fernandez, MM ;

Voldby, J ;

Andersen, JS ;

Kristiansen, K ;

Pandey, A ;

Mann, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (44) :42011-42016

[4]

Differential dimerization and association among resistin family proteins with implications for functional specificity [J].

Chen, J ;

Wang, L ;

Boeg, YS ;

Xia, B ;

Wang, J .

JOURNAL OF ENDOCRINOLOGY, 2002, 175 (02) :499-504

[5]

5′ flanking variants of resistin are associated with obesity [J].

Engert, JC ;

Vohl, MC ;

Williams, SM ;

Lepage, P ;

Loredo-Osti, JC ;

Faith, J ;

Doré, C ;

Renaud, Y ;

Burtt, NP ;

Villeneuve, A ;

Hirschhorn, JN ;

Altshuler, D ;

Groop, LC ;

Després, JP ;

Gaudet, D ;

Hudson, TJ .

DIABETES, 2002, 51 (05) :1629-1634

[6]

Identification of RELMγ, a novel resistin-like molecule with a distinct expression pattern [J].

Gerstmayer, B ;

Küsters, D ;

Gebel, S ;

Müller, T ;

Van Miert, E ;

Hofmann, K ;

Bosio, A .

GENOMICS, 2003, 81 (06) :588-595

[7]

Understanding adipocyte differentiation [J].

Gregoire, FM ;

Smas, CM ;

Sul, HS .

PHYSIOLOGICAL REVIEWS, 1998, 78 (03) :783-809

[8]

FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family [J].

Holcomb, IN ;

Kabakoff, RC ;

Chan, B ;

Baker, TW ;

Gurney, A ;

Henzel, W ;

Nelson, C ;

Lowman, HB ;

Wright, BD ;

Skelton, NJ ;

Frantz, GD ;

Tumas, DB ;

Peale, FV ;

Shelton, DL ;

Hébert, CC .

EMBO JOURNAL, 2000, 19 (15) :4046-4055

[9]

Jonke J, 2002, OBES RES, V10, P1

[10]

Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity [J].

Kim, KH ;

Zhao, L ;

Moon, Y ;

Kang, CH ;

Sul, HS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6780-6785

← 1 2 3 →