CagA-producing Helicobacter pylori and increased risk of gastric cancer:: a nested case-control study in Korea

被引：53

作者：

Gwack, J.

Shin, A.

Kim, C-S

Ko, K-P

Kim, Y.

Jun, J. K.

Bae, J.

Park, S. K.

Hong, Y-C

Kang, D.

Chang, S-H

Shin, H-R

Yoo, K-Y

机构：

[1] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110799, South Korea

[2] Vanderbilt Univ, Med Ctr, Ctr Hlth Serv Res, Nashville, TN USA

[3] Konkuk Univ, Coll Med, Dept Prevent Med, Chungju 380701, Chungcheongbuk, South Korea

[4] Natl Canc Ctr, Res Inst Natl Canc Control & Evaluat, Goyang 410769, Gyeonggi Do, South Korea

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 95卷 / 05期

关键词：

gastric cancer; Helicobacter pylori; CagA; cohort study; Korea;

D O I：

10.1038/sj.bjc.6603309

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR = 3.57, 95% CI 1.05 - 12.14).

引用

页码：639 / 641

页数：3

共 21 条

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[Anonymous], IARC MON EV CARC RIS

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Correa Pelayo, 2004, IARC Sci Publ, P301

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Molecular mechanism of action of major Helicobacter pylori virulence factors [J].