Elevated platelet count features the variant type of BCR/ABL junction in chronic myelogenous leukaemia

被引：35

作者：

Yamagata, T ^{[1
]}

Mitani, K ^{[1
]}

Kanda, Y ^{[1
]}

Yazaki, Y ^{[1
]}

Hirai, H ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,TOKYO 113,JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 94卷 / 02期

关键词：

BCR/ABL; c3-a2; type; chronic myelogenous leukaemia; essential thrombocythaemia; interferon-alpha;

D O I：

10.1046/j.1365-2141.1996.d01-1798.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A variant form of BCR/ABL junction was identified in a patient with chronic myelogenous leukaemia (CML). The BCR/ABL fusion mRNA of this patient showed in-frame junction between BCR exon c3 and ABL exon 2. Although the diagnosis of CML was made, the patient showed clinical features of essential thrombocythaemia (ET) rather than that of typical CML. Treatment with interferon-alpha showed no cytogenetic response, The c3-a2 type of BCR/ABL junction seems to be associated with elevated platelet count and thus could form a novel clinical entity different from typical CML.

引用

页码：370 / 372

页数：3

共 9 条

[1] PHILADELPHIA CHROMOSOMAL BREAKPOINTS ARE CLUSTERED WITHIN A LIMITED REGION, BCR, ON CHROMOSOME-22 [J].

GROFFEN, J ;

STEPHENSON, JR ;

HEISTERKAMP, N ;

DEKLEIN, A ;

BARTRAM, CR ;

GROSVELD, G .

CELL, 1984, 36 (01) :93-99

[2] INDUCTION OF BCR-ABL FUSION GENES BY INVITRO X-IRRADIATION [J].

ITO, T ;

SEYAMA, T ;

MIZUNO, T ;

HAYASHI, T ;

IWAMOTO, KS ;

DOHI, K ;

NAKAMURA, N ;

AKIYAMA, M .

JAPANESE JOURNAL OF CANCER RESEARCH, 1993, 84 (02) :105-109

[3]

LIFSHITZ B, 1988, ONCOGENE, V2, P113

[4]

MURPHY S, 1982, CANCER TREAT REP, V66, P1495

[5] BCR-ABL-INDUCED ONCOGENESIS IS MEDIATED BY DIRECT INTERACTION WITH THE SH2 DOMAIN OF THE GRB-2 ADAPTER PROTEIN [J].

PENDERGAST, AM ;

QUILLIAM, LA ;

CRIPE, LD ;

BASSING, CH ;

DAI, ZH ;

LI, NX ;

BATZER, A ;

RABUN, KM ;

DER, CJ ;

SCHLESSINGER, J ;

GISHIZKY, ML .

CELL, 1993, 75 (01) :175-185

[6] BCR-ABL ONCOPROTEINS BIND DIRECTLY TO ACTIVATORS OF THE RAS SIGNALING PATHWAY [J].

PUIL, L ;

LIU, JX ;

GISH, G ;

MBAMALU, G ;

BOWTELL, D ;

PELICCI, PG ;

ARLINGHAUS, R ;

PAWSON, T .

EMBO JOURNAL, 1994, 13 (04) :764-773

[7]

SAGLIO G, 1990, BLOOD, V76, P1819

[8] FUSED TRANSCRIPT OF ABL AND BCR GENES IN CHRONIC MYELOGENOUS LEUKEMIA [J].

SHTIVELMAN, E ;

LIFSHITZ, B ;

GALE, RP ;

CANAANI, E .

NATURE, 1985, 315 (6020) :550-554

[9]

WADA H, 1995, CANCER RES, V55, P3192

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