Pd(0)/PR3-Catalyzed Intermolecular Arylation of Sp3 C-H Bonds

被引：264

作者：

Wasa, Masayuki ^{[1
]}

Engle, Keary M. ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 29期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

PALLADIUM-CATALYZED ARYLATION; ARYL HALIDES; BORONIC ACIDS; ACTIVATION; AIR;

D O I：

10.1021/ja903573p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd(0)-catalyzed intermolecular arylation of sp(3) C-H bonds has been achieved using PR3/Arl. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive drug molecules. The use of fluorinated aryl iodides also allows for the introduction of fluorine into a molecule of interest.

引用

页码：9886 / +

页数：3

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