Uncoating kinetics of hepatitis A virus virions and provirions

被引：13

作者：

Bishop, NE ^{[1
]}

Anderson, DA ^{[1
]}

机构：

[1] Macfarlane Burnet Ctr Med Res, Hepatitis Res Unit, Fairfield, Vic 3078, Australia

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 07期

关键词：

D O I：

10.1128/JVI.74.7.3423-3426.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogenous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.

引用

页码：3423 / 3426

页数：4

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