Occurrence of portal vein tumor thrombus in hepatocellular carcinoma affects prognosis and survival. A retrospective clinical study of 150 cases

被引:39
作者
Giannelli, G
Pierri, F
Trerotoli, P
Marinosci, F
Serio, G
Schiraldi, O
Antonaci, S
机构
[1] Univ Bari, Sch Med, Sect Med Stat, Dept Internal Med & Publ Hlth, Bari, Italy
[2] Univ Bari, Sch Med, Sect Internal Med, Dept Internal Med Immunol & Infect Dis, Bari, Italy
关键词
hepatocellular carcinoma; metastasis; prognostic factors; tumor invasion; blood vessel metastasis; multivariate analysis;
D O I
10.1016/S1386-6346(02)00027-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. Despite improvements in diagnostic and therapeutic interventions, prognosis and survival are still poor. To identify factors influencing survival, we retrospectively examined 150 consecutive patients with HCC from the time of first diagnosis of cirrhosis to death. In a multivariate analysis, we found that patients with larger HCC lesions had shorter survival, while other pathologic features had no predictive value. The most important and reliable prognostic factor was the occurrence of tumor thrombus of the portal vein (P < 0.01). Child's stage of underlying liver disease was relevant only in the univariate, but not in the multivariate analysis. The survival of patients with HCC is mainly affected by the biological ability of cancer cells to invade surrounding tissue and vessels. More studies are needed to elucidate the mechanisms that modulate tumor cell motility, in order to design more effective therapies. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:50 / 59
页数:10
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