Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. Despite improvements in diagnostic and therapeutic interventions, prognosis and survival are still poor. To identify factors influencing survival, we retrospectively examined 150 consecutive patients with HCC from the time of first diagnosis of cirrhosis to death. In a multivariate analysis, we found that patients with larger HCC lesions had shorter survival, while other pathologic features had no predictive value. The most important and reliable prognostic factor was the occurrence of tumor thrombus of the portal vein (P < 0.01). Child's stage of underlying liver disease was relevant only in the univariate, but not in the multivariate analysis. The survival of patients with HCC is mainly affected by the biological ability of cancer cells to invade surrounding tissue and vessels. More studies are needed to elucidate the mechanisms that modulate tumor cell motility, in order to design more effective therapies. (C) 2002 Elsevier Science B.V. All rights reserved.
机构:
Univ Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USAUniv Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USA
Bergsland, EK
Venook, AP
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机构:
Univ Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USAUniv Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USA
机构:
Univ Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USAUniv Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USA
Bergsland, EK
Venook, AP
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USAUniv Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94143 USA