Chiral Analysis of Ibuprofen Residues in Water and Sediment

被引：139

作者：

Ali, Imran ^{[2
]}

Singh, Prashant ^{[3
]}

Aboul-Enein, Hassan Y. ^{[1
]}

Sharma, Bhavtosh ^{[2
]}

机构：

[1] Natl Res Ctr, Pharmaceut & Med Chem Dept, Pharmaceut & Drug Ind Res Div, Cairo 12311, Egypt

[2] Jamia Millia Islamia, Dept Chem, New Delhi, India

[3] DAV Postgrad Coll, Dept Chem, Dehra Dun, India

来源：

ANALYTICAL LETTERS | 2009年 / 42卷 / 12期

关键词：

Chiral drugs residues; chromatography; environmental matrices; ibuprofen; water resources; CHROMATOGRAPHY-MASS SPECTROMETRY; PERSONAL CARE PRODUCTS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PHARMACEUTICALLY ACTIVE COMPOUNDS; SEWAGE-TREATMENT PLANTS; SOLID-PHASE EXTRACTION; WASTE-WATER; ACIDIC PHARMACEUTICALS; RISK-ASSESSMENT; CLOFIBRIC ACID;

D O I：

10.1080/00032710903060768

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Thousands of organic compounds are present in our water resources and exist in dynamic equilibrium with sediment. Among them are drug and pharmaceutical residues. Many of these residues are chiral, and their metabolites or degradation products may also be chiral in nature. Therefore, the determination of chiral ratio of these chiral compounds is required to predict the exact toxicities. The present article describes the presence of ibuprofen, the third most popular clinically used drug in the world, in water resources, its enantiomeric degradation, and the monitoring of chiral ratio of ibuprofen enantiomers and its degradation products. Attempts have also been made to describe the future scope of chiral analyses of drug and pharmaceutical residues in the environment.

引用

页码：1747 / 1760

页数：14

共 53 条

[1]

Aboul-Enein HY., 2003, Chiral separations by liquid chromatography and related technologies

[2]

Ali I., 2004, Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis

[3]

Ali I., 2005, Water Encyclopedia: Domestic, municipal, and industrial water supply and waste disposal

[4]

Ali I., 2006, INSTRUMENTAL METHODS

[5] Determination of NSAIDs in river sediment samples [J].

Antonic, Jan ;

Heath, Ester .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2007, 387 (04) :1337-1342

[6]

BAILLIE TA, 1989, J PHARMACOL EXP THER, V249, P517

[7] Application of porous membrane-protected micro-solid-phase extraction combined with HPLC for the analysis of acidic drugs in wastewater [J].

Basheer, Chanbasha ;

Chong, Han Guang ;

Hii, Toh Ming ;

Lee, Hian Kee .

ANALYTICAL CHEMISTRY, 2007, 79 (17) :6845-6850

[8] Predicted and measured concentrations for selected pharmaceuticals in UK rivers: Implications for risk assessment [J].

Bound, Jonathan P. ;

Voulvoulis, Nikolaos .

WATER RESEARCH, 2006, 40 (15) :2885-2892

[9] Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity [J].

Brun, Guy L. ;

Bernier, Marc ;

Losier, Rene ;

Doe, Ken ;

Jackman, Paula ;

Lee, Hing-Biu .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2006, 25 (08) :2163-2176

[10] Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability [J].

Brune, Kay .

CURRENT MEDICAL RESEARCH AND OPINION, 2007, 23 (12) :2985-2995

← 1 2 3 4 5 6 →