The regioselective 4-benzylation of 2,4-dihydroxybenzaldehyde

被引：31

作者：

Mendelson, WL ^{[1
]}

Holmes, M ^{[1
]}

Dougherty, J ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT CHEM,KING OF PRUSSIA,PA 19406

来源：

SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 03期

关键词：

D O I：

10.1080/00397919608003653

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective mono-benzylation of the 1-hydroxyl group of 2,4-dihydroxybenzaldehyde (2) to produce 1 under extremely mild basic conditions (NaHCO3 or KF) has been developed. This approach gives improved regioselectivity relative to earlier methods.

引用

页码：593 / 601

页数：9

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