Synthesis and evaluation of cytotoxic activity of arylfurans

被引：20

作者：

de Oliveira, Renata B.

de Souza-Fagundes, Elaine M.

Siqueira, Helen A. J.

Leite, Rodrigo S.

Donnici, Claudio L.

Zani, Carlos L.

机构：

[1] Fiocruz MS, Fdn Oswaldo Cruz, Lab Quim Prod Nat, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, NEQUIM, Dept Quim, Inst Ciencias Exatas, BR-31270901 Belo Horizonte, MG, Brazil

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 06期

关键词：

arylfurans; cytotoxic activity; cancer cells; PBMC;

D O I：

10.1016/j.ejmech.2006.03.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：756 / 760

页数：5

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