Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages

被引：30

作者：

Yayeh, Taddesse ^{[1
]}

Im, Eun Ju ^{[1
]}

Kwon, Tae-Hyung ^{[2
,3
]}

Roh, Seong-Soo ^{[4
]}

Kim, Suk ^{[5
]}

Kim, Ji Hye ^{[6
]}

Hong, Seung-Bok ^{[7
]}

Cho, Jae Youl ^{[6
]}

Park, Nyun-Ho ^{[2
]}

Rhee, Man Hee ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Taegu 702701, South Korea

[2] Gyeongbuk Inst Marine Bioind, Dept Res & Dev, Uljin 767813, South Korea

[3] Andong Natl Univ, Andong 760749, South Korea

[4] Daegu Haany Univ, Coll Korean Med, Dept Herbol, Gyongsan 712715, South Korea

[5] Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Med, Jinju 660701, South Korea

[6] Sungkyunkwan Univ, Dept Genet Engn, Suwon 440746, South Korea

[7] Chungbuk Hlth & Sci Univ, Dept Clin Lab Sci, Chungbuk 363794, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 22卷 / 01期

关键词：

Dieckol; HO-1; Inflammation; Murine macrophages; NF-KAPPA-B; MARINE BROWN ALGA; NITRIC-OXIDE; ECKLONIA-STOLONIFERA; HEME OXYGENASE-1; PHLOROTANNINS; LPS; ANTIOXIDANT; INDUCTION; PATHWAYS;

D O I：

10.1016/j.intimp.2014.06.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Eisenia bicyclis is edible brown algae recognized as a rich source of bioactive derivatives mainly phlorotannins reported for their anti-oxidant properties. Of all phlorotannins identified so far, dieckol has shown the most potent effect in anti-inflammatory, radical scavenging and neuroprotective functions. However, whether dieckol up-regulates hemeoxygenase 1 (HO-1) and this mediates its anti-inflammatory effect in murine macrophages remains poorly understood. Dieckol (12.5-50 mu M) inhibited nitric oxide production and attenuated inducible nitric oxide synthase, phospho (p)-PI-3 K, p-Akt, p-IKK-alpha/beta, p-I kappa B-alpha and nuclear p-NF-kappa Bp65 protein expressions, and NF-kappa B transcriptional activity in LPS (0.1 mu g/ml) stimulated murine macrophages. On the other hand, dieckol up-regulated HO-1 which partly mediated its anti-inflammatory effect in murine macrophages. Thus, dieckol appeared to be a potential therapeutic agent against inflammation through HO-1 up-regulation. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：51 / 58

页数：8

共 37 条

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