Antimitotic activity of glaupalol-related coumarins from Glauddium palmatum

被引：23

作者：

Morita, H ^{[1
]}

Dota, T ^{[1
]}

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 14期

关键词：

antimitotic activity; coumarin; Glaucidium palmatum;

D O I：

10.1016/j.bmcl.2004.05.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new coumarins, glaumacidines A (1) and B (2), and the related coumarins (3-7) have been isolated from the rhizomes of Glaucidium palmatum (Glaucidiaceae). The absolute configurations of 1 and 2 and trans- and cis-glaupadiols (3 and 4, respectively) were elucidated by spectroscopic data, chemical derivatization, and exciton chirality method. Glaupalol (5) enhanced the polymerization of tubulin and affected synergistically with paclitaxel on inhibition of KB cell proliferation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3665 / 3668

页数：4

共 21 条

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