Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

被引：61

作者：

Hoda, Md Nasrul ^{[1
,2
,6
,7
]}

Bhatia, Kanchan ^{[3
]}

Hafez, Sherif S. ^{[4
]}

Johnson, Maribeth H. ^{[5
]}

Siddiqui, Shahneela ^{[2
]}

Ergul, Adviye ^{[4
,6
,7
]}

Zaidi, Syed Kashif ^{[8
]}

Fagan, Susan C. ^{[2
,6
,7
]}

Hess, David C. ^{[2
,6
]}

机构：

[1] Georgia Regents Univ, Dept Med Lab Imaging & Radiol Sci, Augusta, GA 30912 USA

[2] Georgia Regents Univ, Dept Neurol, Augusta, GA 30912 USA

[3] Georgia Regents Univ, Dept Med, Augusta, GA 30912 USA

[4] Georgia Regents Univ, Dept Physiol, Augusta, GA 30912 USA

[5] Georgia Regents Univ, Augusta, GA 30912 USA

[6] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA USA

[7] Charlie Norwood VA Med Ctr, Augusta, GA USA

[8] King Abdul Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah 21589, Saudi Arabia

来源：

TRANSLATIONAL STROKE RESEARCH | 2014年 / 5卷 / 04期

关键词：

Stroke; Embolic stroke; Remote ischemic conditioning; IV-tPA thrombolysis; PLASMINOGEN-ACTIVATOR; CEREBRAL-ISCHEMIA; SEX-DIFFERENCES; NITRIC-OXIDE; TISSUE; RATS; REPERFUSION; COMBINATION; INJURY;

D O I：

10.1007/s12975-013-0318-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Remote ischemic conditioning is neuroprotective in young male rodents after experimental stroke. However, it has never been tested in females whom remain at higher risk of stroke injury after menopause. We tested remote ischemic perconditioning therapy (RIPerC) at 2 h after embolic stroke in ovariectomized (OVX) female mice with and without intravenous tissue plasminogen activator (IV-tPA) treatment. We assessed cerebral blood flow (CBF), neurobehavioral outcomes, infarction, hemorrhage, edema, and survival. RIPerC therapy with and without IV-tPA improved the CBF and neurobehavioral outcomes and reduced the infarction, hemorrhage, and edema significantly. Late IV-tPA alone at 4 h post-stroke neither improved the neurobehavior nor reduced the infarction but aggravated hemorrhage and mortality in OVX mice. RIPerC therapy prevented the increased mortality during late IV-tPA. Our study demonstrates for the first time that RIPerC therapy is effective in OVX females.

引用

页码：484 / 490

页数：7

共 28 条

[1] Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies [J].

Albers, Gregory W. ;

Goldstein, Larry B. ;

Hess, David C. ;

Wechsler, Lawrence R. ;

Furie, Karen L. ;

Gorelick, Philip B. ;

Hurn, Patty ;

Liebeskind, David S. ;

Nogueira, Raul G. ;

Saver, Jeffrey L. .

STROKE, 2011, 42 (09) :2645-2650

[2] Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice [J].

Choudhri, TF ;

Hoh, BL ;

Solomon, RA ;

Connolly, ES ;

Pinsky, DJ .

STROKE, 1997, 28 (11) :2296-2302

[3] The Effect of Ovariectomy and Estrogen on Penetrating Brain Arterioles and Blood-Brain Barrier Permeability [J].

Cipolla, Marilyn J. ;

Godfrey, Julie A. ;

Wiegman, Marchien J. .

MICROCIRCULATION, 2009, 16 (08) :685-693

[4] Assessing Reperfusion and Recanalization as Markers of Clinical Outcomes After Intravenous Thrombolysis in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) [J].

De Silva, Deidre A. ;

Fink, John N. ;

Christensen, Soren ;

Ebinger, Martin ;

Bladin, Christopher ;

Levi, Christopher R. ;

Parsons, Mark ;

Butcher, Ken ;

Barber, P. Alan ;

Donnan, Geoffrey A. ;

Davis, Stephen M. .

STROKE, 2009, 40 (08) :2872-2874

[5]

Dm R, 2012, J THROMBOSIS HAEMOST

[6] Remote Limb Preconditioning and Postconditioning Will It Translate Into a Promising Treatment for Acute Stroke? [J].

Hess, David C. ;

Hoda, Md Nasrul ;

Bhatia, Kanchan .

STROKE, 2013, 44 (04) :1191-1197

[7] Remote Ischemic Perconditioning Is Effective Alone and in Combination With Intravenous Tissue-Type Plasminogen Activator in Murine Model of Embolic Stroke [J].

Hoda, Md Nasrul ;

Siddiqui, Shahneela ;

Herberg, Samuel ;

Periyasamy-Thandavan, Sudharsan ;

Bhatia, Kanchan ;

Hafez, Sherif S. ;

Johnson, Maribeth H. ;

Hill, William D. ;

Ergul, Adviye ;

Fagan, Susan C. ;

Hess, David C. .

STROKE, 2012, 43 (10) :2794-+

[8]

Hoda Md Nasrul, 2011, Exp Transl Stroke Med, V3, P16, DOI 10.1186/2040-7378-3-16

[9] Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat [J].

Hoda, Md Nasrul ;

Singh, Inderjit ;

Singh, Avtar K. ;

Khan, Mushfiquddin .

JOURNAL OF NEUROINFLAMMATION, 2009, 6 :21

[10] The two pathophysiologies of focal brain ischemia: implications for translational stroke research [J].

Hossmann, Konstantin-Alexander .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (07) :1310-1316

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