Is chromatin remodeling required to build sister-chromatid cohesion?

被引：12

作者：

Riedel, CG ^{[1
]}

Gregan, J ^{[1
]}

Gruber, S ^{[1
]}

Nasmyth, K ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.tibs.2004.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromosome segregation during mitosis and meiosis depends on the linkage of sister DNA molecules after replication. These links, known as sister-chromatid cohesion, are provided by a multi-subunit complex called cohesin. Recent papers suggest that chromatin-remodeling complexes also have a role in the generation of sister-chromatid cohesion. It remains unclear whether they do so by facilitating the recruitment of cohesin to specific chromosomal sequences or by modifying an event at replication forks giving rise to cohesion between sister DNAs.

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页码：389 / 392

页数：4

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