An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases

被引：115

作者：

Neuwald, AF

机构：

[1] Natl. Ctr. for Biotech. Information, National Institutes of Health, Bethesda

来源：

PROTEIN SCIENCE | 1997年 / 6卷 / 08期

关键词：

Aur1p; bromoperoxidase; Dri42; PAP2; PgpB; vanadate;

D O I：

10.1002/pro.5560060817

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of a membrane-bound enzyme important in phospholipid signaling, type 2 phosphatidic acid phospha tase, is suggested by sequence motifs shared with a soluble vanadium-dependent chloroperoxidase of known structure, These regions are also conserved in other soluble globular and membrane-associated proteins, including bacterial acid phosphatases, mammalian glucose-6-phosphatases, and the Drosophila developmental protein Wunen. This implies that a similar arrangement of catalytic residues specifies the active sits within both soluble and membrane spanning domains.

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收藏

页码：1764 / 1767

页数：4

相关论文

共 30 条

[1] The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein [J].

Barila, D ;

Plateroti, M ;

Nobili, F ;

Muda, AO ;

Xie, YH ;

Morimoto, T ;

Perozzi, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (47) :29928-29936

[2] Phosphatidate phosphohydrolase and signal transduction [J].

Brindley, DN ;

Waggoner, DW .

CHEMISTRY AND PHYSICS OF LIPIDS, 1996, 80 (1-2) :45-57

[3] Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis [J].

Denu, JM ;

Lohse, DL ;

Vijayalakshmi, J ;

Saper, MA ;

Dixon, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2493-2498

[4] The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity [J].

Dillon, DA ;

Wu, WI ;

Riedel, B ;

Wissing, JB ;

Dowhan, W ;

Carman, GM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (48) :30548-30553

[5] Messenger functions of phosphatidic acid [J].

English, D ;

Cui, Y ;

Siddiqui, RA .

CHEMISTRY AND PHYSICS OF LIPIDS, 1996, 80 (1-2) :117-132

[6] PHOSPHATIDYLCHOLINE BREAKDOWN AND SIGNAL-TRANSDUCTION [J].

EXTON, JH .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1994, 1212 (01) :26-42

[7] Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation [J].

Flores, I ;

Casaseca, T ;

MartinezA, C ;

Kanoh, H ;

Merida, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (17) :10334-10340

[8]

HashidaOkado T, 1996, MOL GEN GENET, V251, P236

[9] Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (Type 2) bound to plasma membranes - Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase [J].

Kai, M ;

Wada, I ;

Imai, S ;

Sakane, F ;

Kanoh, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18931-18938

[10] Molecular properties of enzymes involved in diacylglycerol and phosphatidate metabolism [J].

Kanoh, H ;

Kai, M ;

Wada, I .

JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING, 1996, 14 (1-3) :245-250