Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

被引：2620

作者：

Diebold, SS

Kaisho, T

Hemmi, H

Akira, S

Sousa, CRE ^{[1
]}

机构：

[1] London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England

[2] Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan

[3] RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[4] Japan Sci & Technol Corp, ERATO, Akira Innate Immun Project, Suita, Osaka 5650871, Japan

来源：

SCIENCE | 2004年 / 303卷 / 5663期

关键词：

D O I：

10.1126/science.1093616

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-alpha in response to the wild-type influenza virus. Here, we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88. Single-stranded RNA (ssRNA) molecules of nonviral origin also induce TLR7-dependent production of inflammatory cytokines. These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses.

引用

页码：1529 / 1531

页数：3

共 29 条

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