Optimal Implementations for Reliable Circadian Clocks

被引:20
作者
Hasegawa, Yoshihiko [1 ]
Arita, Masanori [2 ,3 ]
机构
[1] Univ Tokyo, Grad Sch Sci, Dept Biochem & Biophys, Tokyo 1130033, Japan
[2] Natl Inst Genet, Ctr Informat Biol, Shizuoka 4118540, Japan
[3] RIKEN, Ctr Sustainable Resource Sci, Kanagawa 2300045, Japan
关键词
GENE-EXPRESSION; LIGHT; SYSTEM;
D O I
10.1103/PhysRevLett.113.108101
中图分类号
O4 [物理学];
学科分类号
070305 [高分子化学与物理];
摘要
Circadian rhythms are acquired through evolution to increase the chances for survival through synchronizing with the daylight cycle. Reliable synchronization is realized through two trade-off properties: regularity to keep time precisely, and entrainability to synchronize the internal time with daylight. We find by using a phase model with multiple inputs that achieving the maximal limit of regularity and entrainability entails many inherent features of the circadian mechanism. At the molecular level, we demonstrate the role sharing of two light inputs, phase advance and delay, as is well observed in mammals. At the behavioral level, the optimal phase-response curve inevitably contains a dead zone, a time during which light pulses neither advance nor delay the clock. We reproduce the results of phase-controlling experiments entrained by two types of periodic light pulses. Our results indicate that circadian clocks are designed optimally for reliable clockwork through evolution.
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页数:5
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