Obesity and cancer pathogenesis

被引：152

作者：

Berger, Nathan A. ^{[1
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机构：

[1] Case Western Reserve Univ, Sch Med, Dept Med, Ctr Sci Hlth & Soc,Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Ctr Sci Hlth & Soc,Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Dept Genet, Ctr Sci Hlth & Soc,Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

来源：

YEAR IN DIABETES AND OBESITY | 2014年 / 1311卷

关键词：

cancer and obesity; diabetes; murine models; pancreatic cancer; dietary fats; cholesterol; intestinal microbiome; BODY-MASS INDEX; INSULIN-RECEPTOR ISOFORM; POSITIVE FEEDBACK LOOP; DIET-INDUCED OBESITY; MULTIPLE INTESTINAL NEOPLASIA; CAUSE-SPECIFIC MORTALITY; MAMMARY-TUMOR GROWTH; HUMAN GUT MICROBIOTA; ABERRANT CRYPT FOCI; EARLY BREAST-CANCER;

D O I：

10.1111/nyas.12416

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies. Pathophysiologic processes that affect this association are reviewed, with a focus on the relationship between type 2 diabetes mellitus and cancer, lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effects of dietary fats and cholesterol on cancer promotion, and the mechanisms by which the intestinal microbiome affects obesity and cancer.

引用

页码：57 / 76

页数：20

共 213 条

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