Activity-dependent regulation of dendritic growth and patterning

被引：518

作者：

Wong, ROL

Ghosh, A ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[2] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 10期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn941

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

One of the most remarkable features of the developing brain is its ability to undergo structural change in response to experience. Among the cellular elements that show this kind of plasticity are dendrites, which are the components that receive and process synaptic information. Recent observations indicate that calcium signalling in neurons can regulate dendritic growth and remodelling by several mechanisms, and these mechanisms are likely to be key mediators of structural plasticity in the developing brain.

引用

页码：803 / 812

页数：10

共 116 条

[1] EXPERIMENTAL REORGANIZATION OF CEREBELLAR CORTEX .1. MORPHOLOGICAL EFFECTS OF ELIMINATION OF ALL MICRONEURONS WITH PROLONGED X-IRRADIATION STARTED AT BIRTH [J].