Apoptosis in neural development and disease

被引：237

作者：

Nijhawan, D

Honarpour, N

Wang, XD

机构：

[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75235 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2000年 / 23卷

关键词：

caspase; Bcl-2; cytochrome c; Apaf-1; neurodegenerative;

D O I：

10.1146/annurev.neuro.23.1.73

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell death via apoptosis is a prominent feature in mammalian neural development. Recent studies into the basic mechanism of apoptosis have revealed biochemical pathways that control and execute apoptosis in mammalian cells. Protein factors in these pathways play important roles during development in regulating the balance between neuronal life and death. Additionally, mounting evidence indicates such pathways may also be activated during several neurodegenerative diseases, resulting in improper loss of neurons.

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页码：73 / 87

页数：17

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