Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells

被引：18

作者：

Silveira, Alexandra C. ^{[1
]}

Hurst, Douglas R. ^{[1
]}

Vaidya, Kedar S. ^{[1
]}

Ayer, Donald E. ^{[5
]}

Welch, Danny R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35209 USA

[2] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35209 USA

[3] Univ Alabama Birmingham, Dept Pharmacol Toxicol, Birmingham, AL 35209 USA

[4] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35209 USA

[5] Univ Utah, Huntsman Canc Ctr, Salt Lake City, UT 84112 USA

来源：

CANCER LETTERS | 2009年 / 276卷 / 01期

关键词：

SUDS3; BRMS1; Metastasis suppression; Motility; HISTONE DEACETYLASE COMPLEX; BREAST-CANCER; GENE-EXPRESSION; CARCINOMA METASTASIS; INTEGRAL COMPONENT; IDENTIFICATION; PROTEIN; OSTEOPONTIN; COREPRESSOR; MECHANISMS;

D O I：

10.1016/j.canlet.2008.10.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRMS1 and SUDS3 are related members of SIN3-HDAC chromatin remodeling complexes. We hypothesized that they might have overlapping functions and that SUDS3 over-expression could compensate for BRMS1 deficiency. SUDS3 expression was ubiquitous in seven breast cell lines, regardless of metastatic potential. SUDS3 over-expression in BRMS1-non-expressing metastatic cells did not suppress metastasis, motility, osteopontin secretion, or EGF receptor expression, phenotypes associated with BRMS1-mediated metastasis suppression. This study demonstrates functional differences for BRMS1 family members and highlights how the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：32 / 37

页数：6

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