Architecture of fluid intelligence and working memory revealed by lesion mapping

被引：89

作者：

Barbey, Aron K. ^{[1
,2
,3
,4
,5
,6
]}

Colom, Roberto ^{[7
]}

Paul, Erick J. ^{[1
,2
]}

Grafman, Jordan ^{[8
]}

机构：

[1] Univ Illinois, Decis Neurosci Lab, Champaign, IL 61820 USA

[2] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Internal Med, Champaign, IL 61820 USA

[4] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA

[5] Univ Illinois, Dept Speech & Hearing Sci, Champaign, IL 61820 USA

[6] Univ Illinois, Neurosci Program, Champaign, IL 61820 USA

[7] Univ Autonoma Madrid, Fdn CIEN, Fdn Reina Sofia, Madrid, Spain

[8] Rehabil Inst Chicago, Traumat Brain Injury Res Lab, Chicago, IL 60611 USA

来源：

BRAIN STRUCTURE & FUNCTION | 2014年 / 219卷 / 02期

关键词：

Fluid intelligence; Working memory; Prefrontal cortex; Voxel-based lesion-symptom mapping; FRONTAL-LOBE LESIONS; ANTERIOR PREFRONTAL CORTEX; GENERAL INTELLIGENCE; BRAIN-LESIONS; INDIVIDUAL-DIFFERENCES; EXECUTIVE FUNCTION; REASONING ABILITY; PERCEPTUAL SPEED; PARIETAL CORTEX; GRAY-MATTER;

D O I：

10.1007/s00429-013-0512-z

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100123 [人体微生态学]; 100210 [外科学];

摘要：

Although cognitive neuroscience has made valuable progress in understanding the role of the prefrontal cortex in human intelligence, the functional networks that support adaptive behavior and novel problem solving remain to be well characterized. Here, we studied 158 human brain lesion patients to investigate the cognitive and neural foundations of key competencies for fluid intelligence and working memory. We administered a battery of neuropsychological tests, including the Wechsler Adult Intelligence Scale (WAIS) and the N-Back task. Latent variable modeling was applied to obtain error-free scores of fluid intelligence and working memory, followed by voxel-based lesion-symptom mapping to elucidate their neural substrates. The observed latent variable modeling and lesion results support an integrative framework for understanding the architecture of fluid intelligence and working memory and make specific recommendations for the interpretation and application of the WAIS and N-Back task to the study of fluid intelligence in health and disease.

引用

页码：485 / 494

页数：10

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