Dietary n-3 fatty acids in the prevention of lethal cardiac arrhythmias

被引：19

作者：

Leaf, A

Kang, JX

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT MED,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BROCKTON W ROXBURY VET AFFAIRS MED CTR,BOSTON,MA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1997年 / 8卷 / 01期

关键词：

D O I：

10.1097/00041433-199702000-00002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been shown in animals and probably in humans that the n-3 polyunsaturated fatty acids are antiarrhythmic. We report recent studies on the mechanism(s) by which the polyunsaturated fatty acids exert their antiarrhythmic effects. The polyunsaturated fatty acids stabilize the electrical activity of isolated cardiac myocytes by inhibiting sarcolemmal ion channels, so that a stronger electrical stimulus is then required to elicit an action potential and a contraction of the myocyte. This appears at present to be the probable major antiarrhythmic mechanism of the polyunsaturated fatty acids.

引用

收藏

页码：4 / 6

页数：3

相关论文

共 20 条

[1]

*AM HEART ASS, 1995, HEART STROK FACTS 19

[2] PREVENTION OF ISCHEMIA-INDUCED VENTRICULAR-FIBRILLATION BY OMEGA-3-FATTY-ACIDS [J].

BILLMAN, GE ;

HALLAQ, H ;

LEAF, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) :4427-4430

[3]

BURR ML, 1989, LANCET, V2, P757

[4] MEDITERRANEAN ALPHA-LINOLENIC ACID-RICH DIET IN SECONDARY PREVENTION OF CORONARY HEART-DISEASE [J].

DELORGERIL, M ;

RENAUD, S ;

MAMELLE, N ;

SALEN, P ;

MARTIN, JL ;

MONJAUD, I ;

GUIDOLLET, J ;

TOUBOUL, P ;

DELAYE, J .

LANCET, 1994, 343 (8911) :1454-1459

[5]

Gudbjarnason S, 1976, Acta Med Scand Suppl, V587, P17

[6] MODULATION OF DIHYDROPYRIDINE-SENSITIVE CALCIUM CHANNELS IN HEART-CELLS BY FISH OIL FATTY-ACIDS [J].

HALLAQ, H ;

SMITH, TW ;

LEAF, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1760-1764

[7] EFFECTS OF LONG-CHAIN POLYUNSATURATED FATTY-ACIDS ON THE CONTRACTION OF NEONATAL RAT CARDIAC MYOCYTES [J].

KANG, JX ;

LEAF, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9886-9890

[8] PREVENTION AND TERMINATION OF BETA-ADRENERGIC AGONIST-INDUCED ARRHYTHMIAS BY FREE POLYUNSATURATED FATTY-ACIDS IN NEONATAL RAT CARDIAC MYOCYTES [J].

KANG, JX ;

LEAF, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (02) :629-636

[9] Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes [J].

Kang, JX ;

Leaf, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 297 (1-2) :97-106

[10] FREE, LONG-CHAIN, POLYUNSATURATED FATTY-ACIDS REDUCE MEMBRANE ELECTRICAL EXCITABILITY IN NEONATAL RAT CARDIAC MYOCYTES [J].

KANG, JX ;

XIAO, YF ;

LEAF, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3997-4001