Biomineral-inspired fabrication of semi-permeable calcium phosphate-polysaccharide microcapsules

被引:40
作者
Lévêque, I [1 ]
Rhodes, KH [1 ]
Mann, S [1 ]
机构
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
关键词
D O I
10.1039/b204599k
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Mineral-polysaccharide microcapsules are produced by a one-step method in which the deposition of a semipermeable alginate/chitosan membrane around droplets of sodium alginate is coupled with in situ precipitation of amorphous calcium phosphate. Nucleation of calcium phosphate occurs within the membrane by counter-diffusion of Ca2+ and HPO42- ions and can be controlled by the phosphate concentration in the alginate droplets to produce hybrid microcapsules with enhanced mechanical strength and reduced permeability to encapsulated molecules such as haemoglobin and ibuprofen.
引用
收藏
页码:2178 / 2180
页数:3
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