CD4+ T cell levels are decreased during active CMV infection in kidney transplant recipients

被引：12

作者：

Essa, S

Pacsa, AS

Raghupathy, R

Al-Attiyah, R

El-Shazly, A

Said, T

机构：

[1] Kuwait Univ, Fac Med, Dept Microbiol, Kuwait 13110, Kuwait

[2] Minist Publ Hlth Kuwait, Organ Transplant Ctr, Kuwait, Kuwait

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2002年 / 34卷 / 01期

关键词：

transplant; cytomegalovirus; CD4(+);

D O I：

10.1111/j.1574-695X.2002.tb00598.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The numbers of T lymphocytes and T cell subsets (CD2(+), CD3(+), CD4(+), CD8(+)), activated T cells (CD26(+)), B cells (CD19(+)), granulocytes (CD15(+)) and natural killer cells (CD16/56) were monitored by flow cytometry in 79 kidney transplant recipients, 35 of whom had cytomegalovirus infection. The percentages of these cells were correlated with viral load, as determined by cytomegalovirus antigenemia. Development of cytomegaloviral infection coincided with a significant reduction in the percentages of CD4(+) (P < 0.005) and CD3(+) (P < 0.05) cells. Monitoring of lymphocyte subsets may provide useful information on immunological events during cytomegaloviral infection. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.

引用

页码：17 / 22

页数：6

共 26 条

[1] DOWN-REGULATION OF THE CLASS-I HLA HETERODIMER AND BETA-2-MICROGLOBULIN ON THE SURFACE OF CELLS INFECTED WITH CYTOMEGALOVIRUS [J].