Hypothalamic regulation of cortical bone mass: Opposing activity of Y2 receptor and leptin pathways

被引：86

作者：

Baldock, Paul A.

Allison, Susan

McDonald, Michelle M.

Sainsbury, Amanda

Enriquez, Ronaldo F.

Little, David G.

Eisman, John A.

Gardiner, Edith M.

Herzog, Herbert

机构：

[1] St Vincents Hosp, Garvan Inst Med Res, Bone & Mineral Program, Sydney, NSW 2010, Australia

[2] Childrens Hosp Westmead, Dept Orthopaed Res & Biotechnol, Sydney, NSW, Australia

[3] St Vincents Hosp, Garvan Inst Med Res, Neurobiol Program, Sydney, NSW 2010, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

hypothalamus; cortical bone; Y2; receptor; leptin; bone formation;

D O I：

10.1359/JBMR.060705

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

NeuropeptideY-, Y2 receptor (Y2)-, and leptin-deficient mice show similar anabolic action in cancellous bone but have not been assessed in cortical bone. Cortical bone mass is elevated in Y2(-/-) mice through greater osteoblast activity. In contrast, leptin deficiency results in reduced bone mass. We show opposing central regulation of cortical bone.

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收藏

页码：1600 / 1607

页数：8

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