Hepatitis C and not Hepatitis B virus is a risk factor for anti-tuberculosis drug induced liver injury

被引：57

作者：

Kim, Wan Soo ^{[1
]}

Lee, Sang Soo ^{[1
]}

Lee, Chang Min ^{[1
]}

Kim, Hong Jun ^{[1
]}

Ha, Chang Yoon ^{[1
]}

Kim, Hyun Jin ^{[1
]}

Kim, Tae Hyo ^{[1
]}

Jung, Woon Tae ^{[1
]}

Lee, Ok Jae ^{[1
]}

Hong, Jeong Woo ^{[1
]}

You, Hyun Seon ^{[1
]}

Cho, Hyun Chin ^{[2
]}

机构：

[1] Gyeongsang Natl Univ, Sch Med, Gyeongsang Natl Univ Hosp, Dept Internal Med, Gangnam Ro 79, Jinju 660702, Gyeognam, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Internal Med, Palyong Ro 158, Chang Won, South Korea

来源：

BMC INFECTIOUS DISEASES | 2016年 / 16卷

关键词：

Tuberculosis; Treatment; Hepatitis B virus; Hepatitis C virus; Drug induced liver injury; INDUCED HEPATOTOXICITY; TUBERCULOSIS; DISEASE; PYRAZINAMIDE; INFECTION; SEVERITY;

D O I：

10.1186/s12879-016-1344-2

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Background: The risk of anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic viral hepatitis (CVH) is not clear. The aim of this study was to investigate incidence and risk factors associated with TB DILI in CVH and non-CVH patients. Methods: Retrospectively, a total of 128 CVH patients who received anti-TB medication from January 2005 to February 2014 were reviewed. Among these, 83 patients had hepatitis B virus (HBV), 41 patients had hepatitis C virus (HCV) and 4 patients were dual hepatitis B and hepatitis C virus co-infected (HBV + HCV) with 251 non-CVH patients who received anti-TB medication selected as the controls. There were no human immunodeficiency virus co-infected patients. Risk factors for DILI were analyzed using cox regression analysis. Results: The incidence of DILI was significantly higher in the HCV group (13/41 [31.7 %], p < 0.001) and HBV + HCV groups (3/4 [75.0 %], p = 0.002) compared to the control group (25/251 [10.0 %]). The incidence of transient liver function impairment in the hepatitis B virus group was higher than in the control group (18/83 [21.7 %] vs. 27/251 [10.8 %] p = 0.010), but not in DILI (11/83 [13.3 %] vs. 25/251 [10.0 %], p = 0.400). In total patients, HCV, HBV + HCV co-infection, older age, and baseline liver function abnormality were independent factors of DILI. Conclusions: It is recommended to carefully monitor for DILI in patients with HCV or HBV/HCV co-infection, older age, and baseline liver function abnormality.

引用

页数：7

共 32 条

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