Multiple sequence alignment

被引：282

作者：

Edgar, Robert C. ^{[1
]}

Batzoglou, Serafim ^{[1
]}

机构：

[1] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2006年 / 16卷 / 03期

关键词：

D O I：

10.1016/j.sbi.2006.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple sequence alignments are an essential tool for protein structure and function prediction, phylogeny inference and other common tasks in sequence analysis. Recently developed systems have advanced the state of the art with respect to accuracy, ability to scale to thousands of proteins and flexibility in comparing proteins that do not share the same domain architecture. New multiple alignment benchmark databases include PREFAB, SABMARK, OXBENCH and IRMBASE. Although CLUSTALW is still the most popular alignment tool to date, recent methods offer significantly better alignment quality and, in some cases, reduced computational cost.

引用

页码：368 / 373

页数：6

共 39 条

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