Sorbitol accumulation and transmembrane efflux in osmotically stressed JS']JS1 schwannoma cells

被引：18

作者：

Mizisin, AP

Li, L

Calcutt, NA

机构：

[1] Department of Pathology, School of Medicine, University of California, San Diego, San Diego, CA 92093-0612

来源：

NEUROSCIENCE LETTERS | 1997年 / 229卷 / 01期

关键词：

aldose reductase; cell culture; osmoregulation; polyol; Schwann cells; sorbitol dehydrogenase; sorbitol pathway; transmembrane efflux;

D O I：

10.1016/S0304-3940(97)00416-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sorbitol accumulation and transmembrane efflux in JS1 schwannoma cells were examined during osmotic stress in the presence of a sorbitol dehydrogenase (SD) inhibitor and following return to iso-osmotic conditions. SD inhibition promoted sorbitol accumulation under hyperglycemic and/or hyperosmotic conditions, and sorbitol efflux during iso-osmotic incubation was prevented by cooling to 4 degrees C or by quinidine. It appears that sorbitol levels in JS1 cells are dependent on SD activity and that sorbitol is rapidly removed upon restoring isoosmotic conditions. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：53 / 56

页数：4

共 23 条

[1] INCREASE IN ALDOSE REDUCTASE MESSENGER-RNA IN DOG LENS EPITHELIAL-CELLS UNDER HYPERTONIC CONDITIONS
CARPER, D
KANEKO, M
STARK, H
HOHMAN, T
[J]. EXPERIMENTAL EYE RESEARCH, 1990, 50 (06) : 743 - 749
[2] ACTIVATION OF OSMOLYTE EFFLUX FROM CULTURED RENAL PAPILLARY EPITHELIAL-CELLS
FURLONG, TJ
MORIYAMA, T
SPRING, KR
[J]. JOURNAL OF MEMBRANE BIOLOGY, 1991, 123 (03) : 269 - 277
[3] SORBITOL PATHWAY - ENZYME LOCALIZATION AND CONTENT IN NORMAL AND DIABETIC NERVE AND CORD
GABBAY, KH
OSULLIVA.JB
[J]. DIABETES, 1968, 17 (05) : 239 - &
[4] RENAL MEDULLARY ORGANIC OSMOLYTES
GARCIAPEREZ, A
BURG, MB
[J]. PHYSIOLOGICAL REVIEWS, 1991, 71 (04) : 1081 - 1115
[5] SORBITOL PERMEASE - AN APICAL MEMBRANE TRANSPORTER IN CULTURED RENAL PAPILLARY EPITHELIAL-CELLS
GARTY, H
FURLONG, TJ
ELLIS, DE
SPRING, KR
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (05): : F650 - F656
[6] DIABETIC NEUROPATHY - STRUCTURAL-ANALYSIS OF NERVE HYDRATION BY MAGNETIC-RESONANCE SPECTROSCOPY
GRIFFEY, RH
EATON, RP
SIBBITT, RR
SIBBITT, WL
BICKNELL, JM
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 260 (19): : 2872 - 2878
[7] HOHMAN TC, 1991, ADV EXP MED BIOL, V284, P139
[8] VOLUME-SENSITIVE ANION CHANNELS MEDIATE SWELLING-ACTIVATED INOSITOL AND TAURINE EFFLUX
JACKSON, PS
STRANGE, K
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (06): : C1489 - C1500
[9] PERIPHERAL-NERVES IN EARLY EXPERIMENTAL DIABETES - EXPANSION OF ENDONEURIAL SPACE AS A CAUSE OF INCREASED WATER-CONTENT
JAKOBSEN, J
[J]. DIABETOLOGIA, 1978, 14 (02) : 113 - 119
[10] INDUCTION OF ALDOSE REDUCTASE EXPRESSION IN RAT-KIDNEY MESANGIAL CELLS AND CHINESE HAMSTER OVARY CELLS UNDER HYPERTONIC CONDITIONS
KANEKO, M
CARPER, D
NISHIMURA, C
MILLEN, J
BOCK, M
HOHMAN, TC
[J]. EXPERIMENTAL CELL RESEARCH, 1990, 188 (01) : 135 - 140

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