Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review

被引：825

作者：

Li, YC ^{[1
]}

Korol, AB ^{[1
]}

Fahima, T ^{[1
]}

Beiles, A ^{[1
]}

Nevo, E ^{[1
]}

机构：

[1] Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel

来源：

MOLECULAR ECOLOGY | 2002年 / 11卷 / 12期

关键词：

genomic distribution; polymerase slippage; recombination; size constraints; SSR function;

D O I：

10.1046/j.1365-294X.2002.01643.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsatellites, or tandem simple sequence repeats (SSR), are abundant across genomes and show high levels of polymorphism. SSR genetic and evolutionary mechanisms remain controversial. Here we attempt to summarize the available data related to SSR distribution in coding and noncoding regions of genomes and SSR functional importance. Numerous lines of evidence demonstrate that SSR genomic distribution is nonrandom. Random expansions or contractions appear to be selected against for at least part of SSR loci, presumably because of their effect on chromatin organization, regulation of gene activity, recombination, DNA replication, cell cycle, mismatch repair system, etc. This review also discusses the role of two putative mutational mechanisms, replication slippage and recombination, and their interaction in SSR variation.

引用

页码：2453 / 2465

页数：13

共 154 条

[1] CHARACTERIZATION OF A MULTISUBUNIT HUMAN PROTEIN WHICH SELECTIVELY BINDS SINGLE-STRANDED D(GA)N AND D(GT)N SEQUENCE REPEATS IN DNA [J].