Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging

被引：115

作者：

Brickman, Adam M. ^{[1
]}

Zahra, Amir ^{[1
]}

Muraskin, Jordan ^{[1
]}

Steffener, Jason ^{[1
]}

Holland, Christopher M. ^{[2
,3
]}

Habeck, Christian ^{[1
]}

Borogovac, Ajna ^{[4
]}

Ramos, Marco A. ^{[1
]}

Brown, Truman R. ^{[4
,5
]}

Asllani, Iris ^{[5
]}

Stern, Yaakov ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Imaging, Boston, MA 02115 USA

[3] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA

[4] Columbia Univ, Dept Biomed Engn, New York, NY USA

[5] Columbia Univ, Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2009年 / 172卷 / 02期

基金：

美国国家卫生研究院;

关键词：

White matter hyperintensities; Arterial spin labeling; MRI; AMYLOID ANGIOPATHY; ALZHEIMER-DISEASE; PERFUSION MRI; DECLINE; ADULTS; VOLUME;

D O I：

10.1016/j.pscychresns.2008.11.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of this study was to examine cerebral blood flow (CBF) as measured by arterial spin labeling (ASL) in tissue classified as white matter hyperintensities (WMH), normal appearing white matter, and grey matter. Seventeen healthy older adults received structural and ASL MRI. Cerebral blood flow was derived for three tissue types: WMH, normal appearing white matter, and grey matter. Cerebral blood flow was lower in WMH areas relative to normal appearing white matter, which in turn, was lower than grey matter. Regions with consistently lower CBF across individuals were more likely to appear as WMH. Results are consistent with an emerging literature linking diminished regional perfusion with the risk of developing WMH. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：117 / 120

页数：4

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