Synthetic TGF-β antagonist accelerates wound healing and reduces scarring

被引：83

作者：

Huang, JS

Wang, YH

Ling, TY

Chuang, SS

Johnson, FE

Huang, SS

机构：

[1] St Louis Univ, Sch Med, Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[2] St Louis Univ, Sch Med, Dept Surg, St Louis, MO 63104 USA

[3] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[4] China Med Coll, Inst Pharmaceut Chem, Taichung, Taiwan

[5] Taiwan Pig Res Inst, Maioli, Taiwan

[6] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Tao Yuan, Taiwan

来源：

FASEB JOURNAL | 2002年 / 16卷 / 08期

关键词：

hypertrophic scarring; tissue fibrosis; peptantagonist;

D O I：

10.1096/fj.02-0103fje

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wound healing consists of re-epithelialization, contraction and formation of granulation and scar tissue. TGF-beta is involved in these events, but its exact roles are not well understood. Here we demonstrate that topical application of a synthetic TGF-beta antagonist accelerates re-epithelialization in pig burn wounds (100% re-epithelialization in antagonist-treated wounds vs. similar to 70% re-epithelialization in control wounds on postburn day 26) and reduces wound contraction and scarring in standard pig skin burn, pig skin excision and rabbit skin excision wounds. These results support the distinct roles of TGF-beta in the complex process of wound healing and demonstrate the feasibility of manipulating wound healing by TGF-beta antagonist.

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收藏

页码：1269 / +

页数：12

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