Topographic Reorganization of Cerebrovascular Mural Cells under Seizure Conditions

被引：63

作者：

Arango-Lievano, Margarita ^{[1
,2
]}

Boussadia, Badreddine ^{[3
]}

De Terdonck, Lucile Du Trieu ^{[1
,2
]}

Gault, Camille ^{[1
,2
]}

Fontanaud, Pierre ^{[4
]}

Lafont, Chrystel ^{[4
]}

Mollard, Patrice ^{[4
]}

Marchi, Nicola ^{[3
]}

Jeanneteau, Freddy ^{[1
,2
]}

机构：

[1] Univ Montpellier, CNRS, Lab Stress Hormones & Plast, INSERM,Inst Genom Fonct,Dept Neurosci, F-34093 Montpellier, France

[2] Univ Montpellier, CNRS, Lab Stress Hormones & Plast, INSERM,Inst Genom Fonct,Dept Physiol, F-34093 Montpellier, France

[3] Univ Montpellier, CNRS, Lab Cerebrovasc Mech Brain Disorders, Dept Neurosci,Inst Genom Fonct,INSERM, F-34093 Montpellier, France

[4] Univ Montpellier, CNRS, Lab Networks & Rhythms Endocrine Glands, Inst Genom Fonct,Dept Physiol,INSERM, F-34093 Montpellier, France

来源：

CELL REPORTS | 2018年 / 23卷 / 04期

关键词：

PERICYTE DEGENERATION; STATUS EPILEPTICUS; GROWTH-FACTOR; BLOOD-FLOW; PDGF-BB; BRAIN; MECHANISMS; ARTERIAL; EPILEPSY; ADHESION;

D O I：

10.1016/j.celrep.2018.03.110

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Reorganization of the neurovascular unit has been suggested in the epileptic brain, although the dynamics and functional significance remain unclear. Here, we tracked the in vivo dynamics of perivascular mural cells as a function of electroencephalogram (EEG) activity following status epilepticus. We segmented the cortical vascular bed to provide a size- and type-specific analysis of mural cell plasticity topologically. We find that mural cells are added and removed from veins, arterioles, and capillaries after seizure induction. Loss of mural cells is proportional to seizure severity and vascular pathology (e.g., rigidity, perfusion, and permeability). Treatment with platelet-derived growth factor subunits BB (PDGF-BB) reduced mural cell loss, vascular pathology, and epileptiform EEG activity. We propose that perivascular mural cells play a pivotal role in seizures and are potential targets for reducing pathophysiology.

引用

页码：1045 / 1059

页数：15

共 56 条

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