Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

被引：12

作者：

Buckley, Rachel F. ^{[1
,2
]}

Saling, Michael M. ^{[1
,2
]}

Irish, Muireann ^{[3
,4
]}

Ames, David ^{[5
,6
]}

Rowe, Christopher C. ^{[7
,8
,9
]}

Villemagne, Victor L. ^{[7
,8
,9
]}

Lautenschlager, Nicola T. ^{[6
,10
,11
]}

Maruff, Paul ^{[2
,12
]}

Macaulay, S. Lance ^{[13
]}

Martins, Ralph N. ^{[14
,15
,16
]}

Szoeke, Cassandra ^{[5
]}

Masters, Colin L. ^{[2
]}

Rainey-Smith, Stephanie R. ^{[14
,15
]}

Rembach, Alan ^{[2
]}

Savage, Greg ^{[17
]}

Ellis, Kathryn A. ^{[2
,6
]}

机构：

[1] Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic 3010, Australia

[3] Neurosci Res Australia, Sydney, NSW, Australia

[4] Univ New S Wales, Sch Psychol, Sydney, NSW 2033, Australia

[5] Natl Aging Res Inst, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Psychiat, St Vincents Hosp, Acad Unit Psychiat Old Age, Melbourne, Vic 3010, Australia

[7] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[8] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia

[9] Univ Melbourne, Austin Hlth, Dept Med, Melbourne, Vic 3010, Australia

[10] Univ Western Australia, Sch Psychiat & Clin Neurosci, Crawley, Australia

[11] Univ Western Australia, West Australian Ctr Hlth & Ageing, Crawley, Australia

[12] Cogstate Ltd, Melbourne, Vic, Australia

[13] CSIRO, Melbourne, Vic, Australia

[14] Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, Perth, WA, Australia

[15] Hollywood Private Hosp, Sir James McCusker Alzheimers Dis Res Unit, Perth, WA, Australia

[16] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia

[17] Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, Sydney, NSW 2109, Australia

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2014年 / 26卷 / 10期

基金：

英国医学研究理事会;

关键词：

autobiographical memory; beta-amyloid; hippocampal volume; mild cognitive impairment; MILD COGNITIVE IMPAIRMENT; SUBJECTIVE MEMORY COMPLAINTS; LIFE-STYLE AIBL; EPISODIC MEMORY; FUNCTIONAL NEUROANATOMY; INDIVIDUALS; DEPOSITION; RETRIEVAL; DEMENTIA; DECLINE;

D O I：

10.1017/S1041610214001136

中图分类号：

B849 [应用心理学];

学科分类号：

040203 [应用心理学];

摘要：

Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent beta-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical beta-amyloid burden after adjusting for age and apolipoprotein E (APOE) epsilon 4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by beta-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.

引用

页码：1737 / 1746

页数：10

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