Lipases and HDL metabolism

被引：73

作者：

Jin, WJ ^{[1
]}

Marchadier, D ^{[1
]}

Rader, DJ ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2002年 / 13卷 / 04期

关键词：

D O I：

10.1016/S1043-2760(02)00589-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma levels of high-density lipoproteins (HDL) cholesterol are strongly inversely associated with atherosclerotic cardiovascular disease, and overexpression of HDL proteins, such as apolipoprotein A-I in animals, reduces progression and even induces regression of atherosclerosis. Therefore, HDL metabolism is recognized as a potential target for therapeutic intervention of atherosclerotic vascular diseases. The antiatherogenic properties of HDL include promotion of cellular cholesterol efflux and reverse cholesterol transport, as well as antioxidant, anti-inflammatory and anticoagulant properties. The molecular regulation of HDL metabolism is not fully understood, but it is influenced by several extracellular lipases. Here, we focus on new developments and insights into the role of secreted lipases on HDL metabolism and their relationship to atherosclerosis.

引用

页码：174 / 178

页数：5

共 83 条

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