Synthesis, characterization, and self-assembly behaviors of a biodegradable and anti-clotting poly(EDTA-diol-co-butylene adipate glycol urethanes)

被引：10

作者：

Bao, Lixia ^{[1
,2
]}

Luo, Xin ^{[1
]}

Zhang, Dandan ^{[1
]}

Lei, Jingxin ^{[2
]}

Cao, Qiue ^{[1
]}

Wang, Jiliang ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China

[2] Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 35期

基金：

中国国家自然科学基金;

关键词：

POLYMERS; POLYURETHANE; SCAFFOLD; BIOCOMPATIBILITY; FABRICATION; COPOLYMER; DESIGN; GROWTH;

D O I：

10.1039/c4tb00603h

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Anti-clotting EDTA-diol was successfully synthesized by an esterification reaction between EDTA-2Na and poly(ethylene glycol). Novel anti-clotting and biodegradable multi-block polyurethanes were then prepared by EDTA-diol and biodegradable poly(1,4-butylene adipate glycol) (PBA) as the soft chain, and 1,4-butanediol (BDO) and hexamethylene diisocyanate (HDI) as the hard chain, respectively. The effect of the EDTA-diol content in the soft chain of the prepared polyurethanes on mechanical properties, thermal stability, hydrophilicity, and anticoagulant ability was largely investigated by tensile tests, thermogravimetric analysis, contact angle and water absorption measurements, and hemolytic measurement. Self-assembly behaviors of the resulting polyurethanes were also evaluated by fluorescence spectroscopy and transmission electron microscopy. The prepared polyurethanes have large potential applications in the fields of biomedical materials such as tissue engineering and drug carriers.

引用

页码：5862 / 5871

页数：10

共 38 条

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