Decreased frequency of apolipoprotein E ε4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians

被引：86

作者：

Panza, F ^{[1
]}

Solfrizzi, V ^{[1
]}

Torres, F ^{[1
]}

Mastroianni, F ^{[1
]}

Del Parigi, A ^{[1
]}

Colacicco, AM ^{[1
]}

Basile, AM ^{[1
]}

Capurso, C ^{[1
]}

Noya, R ^{[1
]}

Capurso, A ^{[1
]}

机构：

[1] Univ Bari, Dept Geriatr, Ctr Aging Brain, Memory Unit, I-70124 Bari, Italy

来源：

NEUROSCIENCE LETTERS | 1999年 / 277卷 / 01期

关键词：

apolipoprotein E; Alzheimer's disease; centenarians; dementia; Southern Italy; longevity;

D O I：

10.1016/S0304-3940(99)00860-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E (apoE) polymorphism was studied in 79 sporadic late onset Alzheimer's disease (LOAD) patients, 125 un related caregivers or volunteers (19-80 years), and 67 centenarians from Apulia, Southern Italy. The frequency of apoE epsilon 2 allele was higher in centenarians than in LOAD patients, while epsilon 4 was lower. In middle-aged adults, the epsilon 4 allele frequency was higher than in centenarians. The epsilon 4 allele frequency was lower in healthy adults than in LOAD patients, while epsilon 2 was higher. Compared with the allele frequencies of Northern and Central European countries, a geographic trend for epsilon 3 and epsilon 4 alleles in LOAD and middle-aged adults was observed. The frequency of epsilon 3 increased from Northern to Southern Europe, while epsilon 4 decreased significantly. in centenarians, epsilon 2 showed a North-South increasing pattern, while epsilon 4 was in opposite trend. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：53 / 56

页数：4

共 19 条

[1]

Amaducci L, 1997, INT J EPIDEMIOL, V26, P995

[2]

Capurso A, 1997, ARCH GERONTOL GERIAT, V25, P149

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