Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos

被引：52

作者：

Cowan, Carrie R. ^{[1
]}

Hyman, Anthony A. ^{[1
]}

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 12期

关键词：

D O I：

10.1038/ncb1511

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Establishment of polarity in C. elegans embryos is dependent on the centrosome(1). The sperm contributes a pair of centrioles to the egg and these centrioles remain incapable of polarizing the cortex while the egg completes meiosis. Coincident with the establishment of polarity, the centrioles recruit centrosomal proteins(1), several of which are required for polarity(1-3), suggesting that the temporal regulation of centrosome assembly may control the initiation of polarization. We found that cyclin E-Cdk2 is required for the establishment of polarity. Cyclin E-Cdk2 controls the recruitment of centrosomal proteins specifically at the time of polarity establishment. Cyclin E is required for several examples of asymmetric cell division and fate determination in C. elegans and Drosophila(4-6). Here, we suggest a possible mechanism for cyclin E-Cdk2-dependent differentiation: the establishment of cortical polarity by the centrosome.

引用

页码：1441 / U82

页数：11

共 42 条

[21] Cell-cycle control in Caenorhabditis elegans:: how the worm moves from G1 to S [J].

Koreth, J ;

van den Heuvel, S .

ONCOGENE, 2005, 24 (17) :2756-2764

[22] SAS-4 is essential for centrosome duplication in C-elegans and is recruited to daughter centrioles once per cell cycle [J].

Leidel, S ;

Gönczy, P .

DEVELOPMENTAL CELL, 2003, 4 (03) :431-439

[23] Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): Differential conservation of CAKs in yeast and metazoa [J].

Liu, J ;

Kipreos, ET .

MOLECULAR BIOLOGY AND EVOLUTION, 2000, 17 (07) :1061-1074

[24] A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry [J].

Matsumoto, Y ;

Maller, JL .

SCIENCE, 2004, 306 (5697) :885-888

[25] Cyclin E [J].

Möröy, T ;

Geisen, C .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2004, 36 (08) :1424-1439

[26] Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C-elegans embryo [J].

Munro, E ;

Nance, J ;

Priess, JR .

DEVELOPMENTAL CELL, 2004, 7 (03) :413-424

[27] PAR proteins and the cytoskeleton: a marriage of equals [J].

Munro, EM .

CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (01) :86-94

[28] Recycling the cell cycle: Cyclins revisited [J].

Murray, AW .

CELL, 2004, 116 (02) :221-234

[29] PAR proteins and the establishment of cell polarity during C. elegans development [J].

Nance, J .

BIOESSAYS, 2005, 27 (02) :126-135

[30] The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote [J].

O'Connell, KF ;

Maxwell, KN ;

White, JG .

DEVELOPMENTAL BIOLOGY, 2000, 222 (01) :55-70

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