Emotion circuits in the brain

被引:5709
作者
LeDoux, JE [1 ]
机构
[1] NYU, Ctr Neural Sci, New York, NY 10003 USA
关键词
fear; memory; learning; conditioning; amygdala; limbic system;
D O I
10.1146/annurev.neuro.23.1.155
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially fear conditioning. This work has pinpointed the amygdala as an important component of the system involved in the acquisition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala. Some progress has also been made in understanding the cellular and molecular mechanisms that underlie fear conditioning, and recent studies have also shown that the findings from experimental animals apply to the human brain. It is important to remember why this work on emotion succeeded where past efforts failed. It focused on a psychologically well-defined aspect of emotion, avoided vague and poorly defined concepts such as "affect," "hedonic tone," or "emotional feelings," and used a simple and straightforward experimental approach. With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior.
引用
收藏
页码:155 / 184
页数:30
相关论文
共 150 条
[1]   Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory [J].
Abel, T ;
Nguyen, PV ;
Barad, M ;
Deuel, TAS ;
Kandel, ER .
CELL, 1997, 88 (05) :615-626
[2]  
ADOLPHS R, 1995, J NEUROSCI, V15, P5879
[3]  
Aggleton J.P., 1986, EMOTION, V3, P281, DOI [https://doi.org/10.1016/B978-0-12-558703-7.50018-8, DOI 10.1016/B978-0-12-558703-7.50018-8, 10.1016/B978-0-12-558703-7.50018-8]
[4]  
Aggleton J. P., 1992, The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction
[5]  
[Anonymous], 1996, The Emotional Brain
[6]  
[Anonymous], 1986, SYNAPSES CIRCUITS BE
[7]  
[Anonymous], FUNCTIONAL NEUROSURG
[8]  
Armony J. L., 1996, COGN NEUR SOC ABSTR, V3, P76
[9]  
Armony JL, 1998, J NEUROSCI, V18, P2592
[10]   Stimulus generalization of fear responses: Effects of auditory cortex lesions in a computational model and in rats [J].
Armony, JL ;
ServanSchreiber, D ;
Romanski, LM ;
Cohen, JD ;
LeDoux, JE .
CEREBRAL CORTEX, 1997, 7 (02) :157-165