EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies

被引：104

作者：

Busson, P

Keryer, C

Ooka, T

Corbex, M

机构：

[1] CNRS, UMR 8126, F-94805 Villejuif, France

[2] Inst Gustave Roussy, F-94805 Villejuif, France

[3] CNRS, UMR 5537, F-69372 Lyon, France

[4] Fac Med Laennec, F-69372 Lyon, France

[5] Int Agcy Res Canc, Genet Epidemiol Unit, F-69372 Lyon, France

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 08期

关键词：

D O I：

10.1016/j.tim.2004.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concomitant silencing of most other viral genes. Impairment of the interactions of viral proteins with cellular partners or disruption of viral latency might prove to be useful for novel therapeutic strategies.

引用

页码：356 / 360

页数：5

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