Physiological roles of SAPK/JNK signaling pathway

被引：116

作者：

Nishina, H ^{[1
]}

Wada, T ^{[1
]}

Katada, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Physiol Chem, Tokyo 1130033, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2004年 / 136卷 / 02期

关键词：

apoptosis; liver formation; ALAP kinase; SAPK/JNK; stress;

D O I：

10.1093/jb/mvh117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) is activated by many types of cellular stresses and extracellular signals. Recent studies, including the analysis with knockout mice, have led to progress towards understanding the physiological roles of SAPK/JNK activation in embryonic development in addition to immune responses. SAPK/JNK activation plays essential roles in organogenesis during mouse development by regulating cell survival, apoptosis, and proliferation. Two SAPK/JNK activators, SEK1 and MKK7, are required for fetal liver formation and full activation of SAPK/JNK, which responds to various stimuli in an all-or-none manner. This article focuses on physiological roles of SAPK/JNK activation in fetal liver formation and in apoptosis regulation.

引用

页码：123 / 126

页数：4

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