Mixed pulse vaccination strategy in epidemic model with realistically distributed infectious and latent times

In this paper we study the use of a pulse vaccination strategy to eradicate infectious diseases modelable by epidemic model having gamma distributed infectious and latent time. We demonstrate the global asymptotic stability of the eradication solution for a general model in which co-presence of a continuous vaccination strategy, the non-permanent duration of the immunization and the emerging problem of the vaccine failures are considered. (C) 2003 Elsevier Inc. All rights reserved.