Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys

被引：52

作者：

Ham, KD ^{[1
]}

Carlson, CS ^{[1
]}

机构：

[1] Univ Minnesota, Coll Vet Med, Dept Vet Diagnost Med, St Paul, MN 55108 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 05期

关键词：

primate; arthritis; estrogen; bone histomorphometry;

D O I：

10.1359/JBMR.040309

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ERT decreases the severity of OA in OVX cynomoigus monkeys. We show that bone formation is greater in subchondral bone compared with epiphyseal/metaphyseal cancellous bone of the proximal tibia in these animals and that ERT decreases bone formation in both sites. ERT may decrease the risk of OA by decreasing bone formation in the SC bone.

引用

页码：823 / 829

页数：7

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