Autophagy in infection, inflammation and immunity

被引：1549

作者：

Deretic, Vojo ^{[1
]}

Saitoh, Tatsuya ^{[2
]}

Akira, Shizuo ^{[2
]}

机构：

[1] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[2] Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 10期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; BCL-X-L; 3,000 SHARED CONTROLS; HERPES-SIMPLEX-VIRUS; SELECTIVE AUTOPHAGY; DENDRITIC CELLS; I INTERFERON; BECLIN; ANTIBACTERIAL AUTOPHAGY;

D O I：

10.1038/nri3532

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and through effects on the secretion of immune mediators. Moreover, autophagy contributes to antigen presentation and to T cell homeostasis, and it affects T cell repertoires and polarization. Thus, as we discuss in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.

引用

页码：722 / 737

页数：16

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